Controle de qualidade de xampu de cetoconazol: avaliação da eficácia.

Abstract

The mycotic infections affecting humans relate in different ways, presenting as superficial mycoses, so easy to treat systemic mycoses, disseminated in the body, which can become life-threatening. In the case of the scalp, seborrheic dermatitis and dandruff are the main manifestations attributed to fungi, especially those of the genus Malassezia, with higher prevalence species Malassezia furfur. The ketoconazole shampoo is one of the most widely used for dandruff and seborrheic dermatitis treatment, and the 2% concentration is the most commonly conveyed in the shampoos formulation, but has presented problems of stability. This study aimed to evaluate the microbiological efficacy of ketoconazole shampoos in conventional and microemulsion formulation against strains of Candida albicans. The ketoconazole potency present in the shampoo was determined by the agar diffusion method - cylinder plates with 2 x 2 design and the determination of ketoconazole shampoos in the UV / visible spectrophotometry. The parameters used for conducting microbiological testing were: Candida albicans as a test microorganism, inoculum concentration of 0.5% agar culture medium, Sabouraud dextrose 2%, concentration of solutions 100 and 200 mg / ml and incubation the plates for 48 hours, 37 ° C. The potency of the microemulsion shampoo compared to conventional shampoo was 99.13%, ie, the microemulsion shampoo has similar potency to conventional shampoo, with respect to the determination by UV / visible spectrophotometry showed the microemulsion shampoo content of 101.07% higher than the theoretical concentration stipulated while conventional shampoo submitted content 86.15%. Therefore, the microemulsion ketoconazole shampoo is anchored with a promising alternative in the treatment of dandruff.