Please use this identifier to cite or link to this item: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37238
Full metadata record
DC FieldValueLanguage
dc.publisher.countryBrasilpt_BR
dc.publisher.initialsUFCGpt_BR
dc.subject.cnpqFarmácia.pt_BR
dc.subject.cnpqQuímica.pt_BR
dc.titleAnticonvulsant effect of a natural compound 𝞪,β-epoxy-carvone and its action on the nerve excitability.pt_BR
dc.date.issued2008-
dc.description.abstractThe anticonvulsant effect of 𝞪,β-epoxy-carvone (EC), a monoterpene monocyclic, was investigated in three animal models. EC at 300 or 400 mg/kg promoted protection of 75% and 87.5%, respectively, against convulsions induced chemically by pentylenetetrazole (PTZ) and it was efficient in prevents the tonic convulsions induced by maximal electroshock (MES) in doses of 200, 300 or 400 mg/kg, resulting in 25%, 25% and 100% of protection, respectively. This monoterpene was also capable to promote an increase of latency for development of convulsions induced by picrotoxin (PIC) at 300 or 400 mg/kg and presented a significant protection against convulsions at doses of 200, 300 or 400 mg/kg, resulting in 12.5%, 12.5% and 100% of protection, respectively. On the other hand, the anticonvulsant effect of EC, was not affected by pretreatment with flumazenil (FLU), a selective antagonist of benzodiazepine site of GABAA receptor. Additionally was observed that EC treatment reduced the levels of in vitro lipoperoxidation and decreased (21.2%) the amplitude of compound action potential after 30 min of incubation. The present results clearly indicate the ability of EC to modulate the anticonvulsant and antioxidant effects. However, our data sug- gests that the action mechanisms are not due a direct activation of the GABAA benzodiazepine receptors, but could be associated with the reduction of isolated nerve excitability, possibly involving a voltage-gated Na+ channels blockade.-
dc.identifier.urihttp://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37238-
dc.date.accessioned2024-08-09T17:43:40Z-
dc.date.available2024-08-09-
dc.date.available2024-08-09T17:43:40Z-
dc.typeArtigo de Periódicopt_BR
dc.subject𝞪,β-epoxy-carvonept_BR
dc.subjectAnticonvulsant effect - 𝞪,β-epoxy-carvonept_BR
dc.subjectNerve excitabilitypt_BR
dc.subjectConvulsions inducedpt_BR
dc.subjectAnticonvulsant activitypt_BR
dc.subjectEssential oilspt_BR
dc.subjectMonoterpenept_BR
dc.subjectEpilepsypt_BR
dc.subjectIsolated nervept_BR
dc.subjectCompound action potentialpt_BR
dc.subjectAntioxidantpt_BR
dc.subjectEfeito anticonvulsivante - 𝞪,β-epoxy-carvonept_BR
dc.subjectExcitabilidade nervosapt_BR
dc.subjectConvulsões induzidaspt_BR
dc.subjectAtividade anticonvulsivantept_BR
dc.subjectÓleos essenciaispt_BR
dc.subjectMonoterpenopt_BR
dc.subjectEpilepsiapt_BR
dc.subjectNervo isoladopt_BR
dc.subjectPotencial de ação do compostopt_BR
dc.subjectAntioxidantept_BR
dc.rightsAcesso Abertopt_BR
dc.creatorALMEIDA, Reinaldo Nóbrega de.-
dc.creatorSOUSA, Damião Pergentino de.-
dc.creatorNÓBREGA, Franklin Ferreira de Farias.-
dc.creatorCLAUDINO, Fladmir de Sousa.-
dc.creatorARAÚJO, Demétrius Antonio Machado.-
dc.creatorLEITE, José Roberto.-
dc.creatorMATTEI, Rita.-
dc.publisherUniversidade Federal de Campina Grandept_BR
dc.languageengpt_BR
dc.title.alternativeEfeito anticonvulsivante de um composto natural 𝞪,β-epóxi-carvona e sua ação na excitabilidade nervosa.pt_BR
dc.identifier.citationALMEIDA, Reinaldo Nóbrega de; SOUSA, Damião Pergentino de; NÓBREGA, Franklin Ferreira de Farias; CLAUDINO, Fladmir de Sousa; ARAÚJO, Demétrius Antonio Machado; LEITE, José Roberto; MATTEI, Rita. Anticonvulsant effect of a natural compound 𝞪,β-epoxy-carvone and its action on the nerve excitability. Revista Elsevier. Neuroscience Letters, v. 443, p. 51-55, 2008. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37238pt_BR
Appears in Collections:Artigos Científicos - CDSA

Files in This Item:
File Description SizeFormat 
ANTICONVULSANT EFFECT OF A NATURAL COMPOUND - ARTIGO DE PERÓDICO CDSA 2008.pdfAnticonvulsant effect of a natural compound 𝞪,β-epoxy-carvone and its action on the nerve excitability. - Artigo de Periódico CDSA 2008291.4 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.