Efeitos da detomidina associada ou não ao sulfato de atropina sobre a produção lacrimal, diâmetro pupilar e outros parâmetros fisiológicos de gatos domésticos.

Abstract

Evaluation of lacrimal production and pupillary diameter of domestic cats anesthetized by detomidine associated or not with atropine sulfate. The objective of this study was to compare the effects of detomidine associated or not with atropine sulfate on lacrimal production, pupillary diameter and physiological parameters of domestic cats. Were selected six healthy animals, which participated in two experimental groups, denominated GD and GDA, with intervals of fifteen days at least between each protocol. GD group received a placebo solution (0.9% NaCl) intramuscularly (IM) in a volume equivalent to atropine sulfate dose and 10 minutes after detomidine was administered (GD) at a dose of 0.1 mg/kg IM. In GDA group, atropine sulfate was administered at a dose of 0.044 mg/kg IM and 10 minutes after, detomidine was administered in the same dose and route used in GD. In both groups the evaluations were initiated before drug administration (M0), 10 minutes after application of the placebo solution (0.9% NaCl) or atropine (M1), 10 minutes after the application of detomidine ( M2) and from 20 to 20 minutes after M2 and for 60 minutes (M3, M4 and M5). The parameters evaluated were: heart rate (HR), respiratory rate (RR), body temperature (BT), systolic blood pressure (SBP) and electrocardiographic variables, which were which were submitted to analysis of variance for "K" dependent and independent samples parametric or nonparametric and descriptive analysis (p = 0.05), followed by Tukey test When comparing the GDA and GD groups, we observed that the animals from both groups had a decreased in lacrimal production , being that in GDA group the reduction was bigger than GD group at all times. As regards to the pupillary diameter, in both groups caused an increase, however GDA presented most striking mydriasis. In relation to physiological parameters, the two groups caused discreet changes, being that GDA had a significantly increased HR. Blood pressure reduced in the animals from GD, whereas the GDA showed a significant increase. Almost all electrocardiographic variables remained unchanged, except the Q-T interval, which showed considerable increase. The results showed that detomidine, both isolated as associated with atropine sulfate, caused a significant decrease in lacrimal production and increased pupillary diameter of cats. These drugs should be used with caution in surgical patients and those with previous changes in lacrimal production. The use of these drugs did not cause changes in physiological parameters.